DNA photocleavage using texaphyrins

US5607924A · kind A · utility

Assignees

• Pharmacyclics LLC · US
• Board of Trustees, Univ. of TX Sys. · US

Inventors

• Darren Magda · Cupertino, US
• Jonathan L. Sessler · Austin, US
• Brent L. Iverson · Austin, US
• Petra I. Sansom · Austin, US
• Meredith Wright · San Jose, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Mar 4, 1997
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/147777
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.