Patent · US Expired

Piperazides of substituted phenylalanine derivatives as thrombin inhibitors

US5607937A · kind A · utility

14Cited by

0References

19Claims

0Family size

Assignee

PENTAPHARM AG · CH

Inventors

Joerg Stuerzebecher · Erfurt, DE
Helmut Vieweg · Rheinfelden (Baden), DE
Peter Wikstroem · Oberwil, CH
Christoph Adler · Reinach, CH

Key dates

Filing date	Jan 5, 1995
Grant date	Mar 4, 1997
Priority date	—
Expiry date	Jan 5, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D311/70
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to D,L-, L- and D-phenylalanine piperazides of formula (I) defined in claim 1 that inhibit blood coagulation, and thrombin and/or trypsin, respectively. The compounds are extraordinarily absorbable after oral, intraduodenal and in particular rectal administration and show only a low toxicity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.