Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
US5608056A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1994 |
| Grant date | Mar 4, 1997 |
| Priority date | — |
| Expiry date | Sep 21, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula: ##STR1## in which R.sup.1 is carboxy or protected carboxy, PA1 R.sup.2 is 1-hydroxyethyl, PA1 R.sup.3 is methyl, PA1 R.sup.4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lower)alkyl, optionally substituted imidazol-1-yl(C.sub.2 -C.sub.3)alkyl, optionally substituted imidazol-5-yl-(lower)alkyl, optionally substituted imidazol-2-yl-(lower)alkyl, optionally substituted pyrazol-4-(or 5-)yl(lower)alkyl, optionally substituted pyrazol-1-ylethyl, optionally substituted triazolyl(lower)alkyl, optionally substituted pyrimidinyl(lower)alkyl, optionally substituted dihydropyrimidinyl(lower)alkyl, or optionally substituted (2,3-dihydroimidazo-[1,2-b]pyrazol-1-yl)ethyl, and PA1 R.sup.5 is hydrogen or imino-protective group, and pharmaceutically acceptable salts thereof, which have antimicrobial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.