Process for preparing 1,4,8,11-tetraazacyclotetradecane
US5608061A · kind A · utility
12Cited by
4References
20Claims
0Family size
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Key dates
| Filing date | Aug 2, 1995 |
| Grant date | Mar 4, 1997 |
| Priority date | — |
| Expiry date | Aug 2, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for preparing 1,4,8,11-tetraazacyclotetradecane comprising the tetratosylation of an acyclic tetraamine to obtain a tetratoluenesulfonamide compound in a first step, the cyclization of said sulfonamide compound to obtain tetratosyl cyclam in a second step, and the detosylation of tetratosyl cyclam in a third step followed by basification to obtain the desired 1,4,8,11-tetraazacyclotetradecane.
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