Enantioselective process for the preparation of chiral triaryl derivatives and chiral intermediates for use therein
US5608070A · kind A · utility
48Cited by
16References
16Claims
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Key dates
| Filing date | Dec 21, 1994 |
| Grant date | Mar 4, 1997 |
| Priority date | — |
| Expiry date | Dec 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An enantioselective multi-stage process is described which uses as a starting material an .alpha.,.beta.-unsaturated olefin of formula (1): EQU Ar--CH.dbd.C(R.sup.4)COAux (1) where Ar and R.sup.4, which may be the same or different, is each a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; and Aux is the residue of a chiral (R- or S-) auxiliary. In the process, the olefin is converted to a chiral triarylethane which is of use in medicine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.