Methods and apparatus for the generation of chemical libraries
US5609826A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1995 |
| Grant date | Mar 11, 1997 |
| Priority date | — |
| Expiry date | Apr 17, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N35/028
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks. An inert atmosphere in the reaction block is maintained by a top and (optional) bottom seal. A synthesis support may be introduced into each reaction chamber as a slurry, and the top septum fastened. A needle pipettes reagents from an array of reagent containers…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.