Treatment methods using metal-binding targeted polypeptide constructs
US5609847A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Mar 11, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method of treating a patient in need thereof, including a need for diagnosis or treatment, comprising the administration of a metal complex of a polypeptide construct. The construct comprises a compound of the formula (I): ##STR1## in which, "B" is a hydrocarbon backbone, PA1 "P" is a polypeptide capable of targeting particular-cells, tissues or organs of the body, PA1 "A" may be the group --NR'--NR"-- or the group --NR'--NR"--L-- in which L may be an aliphatic or aromatic linker group, PA1 R, R', and R" may be the same or different and may be hydrogen or an aliphatic group, PA1 m is an integer .gtoreq.2, provided that the groups R, R', R", L and "P" of a given chain may be the same or different from the groups R, R', R", L and "P" of another chain, PA1 n is an integer .gtoreq.0; PA1 or a pharmaceutically acceptable salt thereof. The constructs of the present invention are capable of binding a variety of metallic species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.