Microspheres for the controlled release of water-soluble substances and process for preparing them
US5609886A · kind A · utility
17Cited by
9References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 26, 1995 |
| Grant date | Mar 11, 1997 |
| Priority date | — |
| Expiry date | Jul 26, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2985
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.