Methods of preventing viral replication

US5610050A · kind A · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Hubert E. Blum · Glückstadt, DE
• Tsanyang Liang · Brookline, US
• Eithan Galun · Holon, IL
• Jack R. Wands · Central Falls, US

Key dates

• Filing date: Apr 23, 1993
• Grant date: Mar 11, 1997
• Expiry date: Apr 23, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2730/10161
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.