Transgenic, cross-linked hemoglobin
US5610137A · kind A · utility
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3Claims
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Key dates
| Filing date | Jul 30, 1993 |
| Grant date | Mar 11, 1997 |
| Priority date | — |
| Expiry date | Jul 30, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Transgenic, recombinantly cross-linked polymeric human hemoglobins suitable as cell-free blood substitutes have been produced. A plurality of DNA constructs have been designed for efficient expression of modified human hemoglobins in the erythrocytes of the non-human transgenic animals. Substantially pure, non-immunogenic, artificial human hemoglobins are then easily obtained from the erythroid cells of the transgenic animals.
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