Patent · US Expired

2,3-disubstituted isoxazolidines, a process for their preparation, agents containing them, and their use

US5610146A · kind A · utility

1Cited by

0References

11Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Stephan Henke · Bad Soden am Taunus, DE
Dietrich Brocks · Wiesbaden, DE
Volkmar G unzler · Marburg, DE

Key dates

Filing date	Feb 24, 1995
Grant date	Mar 11, 1997
Priority date	—
Expiry date	Feb 24, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K5/0819
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sup.1 represents CO, CS, C.dbd.NH, CN-alkyl, CN--O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sup.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; A.sup.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.