Patent · US Expired

Esters of thienyl carboxylic acids and amino alcohols and their quaternization products

US5610163A · kind A · utility

87Cited by

1References

16Claims

0Family size

Assignee

Boehringer Ingelheim GmbH · DE

Inventors

Rolf Banholzer · Stuttgart, DE
Rudolf Bauer · Hallerndorf, DE
Richard Reichl · Ingelheim am Rhein, DE

Key dates

Filing date	Mar 16, 1995
Grant date	Mar 11, 1997
Priority date	—
Expiry date	Mar 16, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D451/10
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and: PA1 (a) A is 3.alpha.-(6.beta., 7.beta.-epoxy)-tropanyl methobromide and R.sub.1 is 2-thienyl; PA1 (b) A is 3.alpha.-(6, 7dehydro)-tropanyl methobromide and R.sub.1 is 2-thienyl; PA1 (c) A is 3.beta.-tropanyl methobromide and R.sub.1 is 2-thienyl; and, PA1 (d) A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide and R.sub.1 is cyclopentyl. These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.