Non-infectious foot-and-mouth disease viruses

US5612040A · kind A · utility

Assignee

• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Peter Mason · Somerville, US
• Barry Baxt · Valley Stream, US
• Elizabeth Reider · Westbrook, US
• Analia Berinstein · Södra Esplanaden, AR
• Angray Kang · Carlsbad, US

Key dates

• Filing date: Apr 7, 1995
• Grant date: Mar 18, 1997
• Expiry date: Apr 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/32122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A safe, effective vaccine for the protection of susceptible animals against foot-and-mouth disease has been produced. The vaccine comprises a mutant virus from which the amino acid sequence Gly-Val-Arg-Gly-Asp-Phe (SEQ ID NO: 8) from the G-H loop of VP1 has been deleted and replaced with the amino acid sequence Asn-Pro. The mutant virus retains its antigenicity but is not infectious.