Method for identifying tumor cells in cell cycle arrest
US5612185A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1994 |
| Grant date | Mar 18, 1997 |
| Priority date | — |
| Expiry date | Sep 15, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/813
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are methods for the identification and characterization of tumor cell types present within malignant populations, and novel methods of cancer treatment. Tumor cells in cell cycle arrest have been identified, purified and characterized according to their size, altered morphology, surface phenotype and expression of oncogenes. Tumor cell cycle arrest can be induced in mice lacking an immune system solely upon administration of anti-idiotype antibodies. Methods of manipulating specific signals from the cell surface to alter the malignant phenotype of transformed cells are disclosed, as are methods for either eliminating or specifically maintaining tumor cells in cell cycle arrest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.