Recombinant production of a human interferon (IFN)-gamma antagonist cytokine
US5612195A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1994 |
| Grant date | Mar 18, 1997 |
| Priority date | — |
| Expiry date | Aug 29, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A cytokine that is a specific antagonist of induction by interferon-gamma of the expression of class II histocompatibility antigens at the cell surface is disclosed. The cytokine is naturally secreted by cells or is the expression product of an exogenous DNA sequence in prokaryotic or eukaryotic cells. Also disclosed is a DNA sequence that codes, on expression in a host cell, for a cytokine having a biological activity that is a specific antagonist of induction by interferon-gamma of the expression of class II histocompatibility antigens at the cell surface. A method for preparing the cytokine is further disclosed. Finally, a therapeutic composition containing the cytokine is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.