Method and apparatus for encapsulation of biologically-active substances in cells
US5612207A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 18, 1995 |
| Grant date | Mar 18, 1997 |
| Priority date | — |
| Expiry date | Dec 18, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2202/0429
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in a red blood cell, characterized by an optionally automated, continuous-flow, self-contained electroporation system which allows withdrawal of blood from a patient, separation of red blood cells, encapsulation of a biologically-active substance in the cells, and optional recombination of blood plasma and the modified cells, thereby producing blood with modified biological characteristics. The present invention is particularly suited for use to encapsulate allosteric effectors of hemoglobin, thereby reducing the affinity of erythrocytes for oxygen and improving the release of oxygen from erythrocytes in tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.