Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A · kind A · utility
16Cited by
23References
19Claims
0Family size
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Key dates
| Filing date | May 24, 1993 |
| Grant date | Mar 18, 1997 |
| Priority date | — |
| Expiry date | May 24, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/42
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.