Nitrosylated neuropeptides

US5612314A · kind A · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• TRUSTEES OF BOSTON UNIVERSITY · US

Inventors

• Jonathan S. Stamler · Chapel Hill, US
• Inigo Saenz de Tejada · Madrid, ES

Key dates

• Filing date: Apr 21, 1995
• Grant date: Mar 18, 1997
• Expiry date: Apr 21, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Neuropeptides, particularly vasoactive intestinal peptide(VIP) and fragments, mutations and derivatives thereof that have corresponding activities to which have been directly or indirectly linked at least one NO or NO.sub.2 group, and their uses, including the relaxation of smooth muscle in several tissues, including vascular smooth muscle (e.g., aorta) and nonvascular smooth muscle (e.g. trachea, sphincter of Oddi, gastrointestinal smooth muscle and corpus cavernosum smooth muscle), and particularly also for the diagnosis and treatment of human male impotence.