Brominated hexahydroxybiphenyl derivatives

US5612341A · kind A · utility

Assignees

• Biotech Research Laboratories · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Kuo-Hsiung Lee · Chapel Hill, US
• Yoshiki Kashiwada · Niigata, JP
• Lan Xie · Chapel Hill, US
• Louis Mark Cosentino · Springfield, US
• Mark Manak · Laurel, US
• Jing XIE · Shanghai, CN
• Yung-Chi Cheng · Woodbridge, US
• Robert Kilkulskie · Shrewsbury, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Mar 18, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are derivatives of 4,4'-dimethoxy-5,6,5'6'-bimethylenedioxy 2,2'-dimethoxycarbonyl biphenyl (DDB) which were synthesized and found to have anti-HIV activity. Of the compounds studied, 3,3'-dibromo DDB and 3-bromo-DDB initially exhibited the greatest anti-HIV activity.