Active carbonates of polyalkylene oxides for modification of polypeptides
US5612460A · kind A · utility
294Cited by
16References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 17, 1994 |
| Grant date | Mar 18, 1997 |
| Priority date | — |
| Expiry date | Feb 17, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.