Process for making HIV protease inhibitors

US5612484A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• David Askin · Hackettstown, US
• Jess Sager · Bound Brook, US
• Kai Rossen · Hanau, DE
• Ralph P. Volante · Rahway, US
• Paul J. Reider · Westfield, US

Key dates

• Filing date: May 18, 1995
• Grant date: Mar 18, 1997
• Expiry date: May 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for making a clinically efficacious HIV protease inhibitor Compound J eliminates one step in its synthesis, by an improved, alternative synthesis of the 2(S)-4-picolyl-2-piperazine-t-butyl-carboxamide intermediate.