High molecular weight polymer-based prodrugs
US5614549A · kind A · utility
182Cited by
20References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 30, 1995 |
| Grant date | Mar 25, 1997 |
| Priority date | — |
| Expiry date | Jan 30, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C331/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active nucleophile; PA1 M is X or Q; PA1 x is an electron withdrawing group; PA1 Q is a moiety containing a free electron pair positioned five or six atoms from Y'; PA1 Y and Y' are oxygen or sulfur; PA1 R is a polyalkylene oxide; and PA1 Z is OH, C.sub.1-4 alkyl moieties or ##STR2## are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.