Inhibitors of fatty acid synthesis as antimicrobial agents
US5614551A · kind A · utility
47Cited by
23References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 24, 1994 |
| Grant date | Mar 25, 1997 |
| Priority date | — |
| Expiry date | Jan 24, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fatty acid synthase (FAS) is overexpressed by certain infectious organisms that are resistant to most currently available antibiotics. Contrarywise, little FAS expression is identified in patient tissues. Inhibition of fatty acid synthesis is thus selectively toxic to invasive cells, while patient cells with low FAS activity are resistant. This invention provides a method of treating septic patients where fatty acid synthesis by invading cells is inhibited with resultant interruption of the disease process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.