Process for enantioselective hydrogenation of the oxo C.dbd.O double bond
US5614641A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1995 |
| Grant date | Mar 25, 1997 |
| Priority date | — |
| Expiry date | Mar 9, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/821
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention concerns a process for enantioselective catalytic hydrogenation of the ketone C.dbd.O double bond to a secondary alcohol function, said process using a neutral ruthenium complex as the catalyst and a compound containing a C.dbd.O group as the substrate to be hydrogenated, characterised in that it comprises hydrogenation of the substrate using a diallyl (diphosphino) ruthenium compound with formula ##STR1## where al preferably represents CH.sub.2 CH.dbd.CH.sub.2 or CH.sub.2 C(CH.sub.3).dbd.CH.sub.2, PA0 Q represents a hydrocarbon bridge containing at least two catenary carbon atoms and which can contain one to four catenary heteroatoms selected from O, S, N and Si, PA0 R.sup.1 to R.sup.4 may be identical or different and each represents a C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.7 cycloalkyl or C.sub.6 -C.sub.12 aryl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.