Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
US5616330A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1994 |
| Grant date | Apr 1, 1997 |
| Priority date | — |
| Expiry date | Jul 19, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to a composition of a taxine in a stable oil-in-water emulsion for intravenous administration. The invention also relates to a method for incorporating a taxine into an oil and making a stable oil-in-water emulsion. The composition includes a taxine, an oil, water and a surfactant. In a preferred embodiment, the taxine is taxol, the oil is safflower oil and the surfactant is lecithin, The taxine is incorporated into the oil by dissolving the taxine in a solution of an oil and a taxine co-solvent, such as isopropanol, for example. The co-solvent then is removed to form a solution of the taxine in oil. This solution may be dispersed in water with a surfactant to form a stable oil-in-water emulsion for intravenous administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.