Process for producing monoclonal antibodies against human T cell receptor elements using recombinant DNA vectors, and cells transfected thereby
US5616472A · kind A · utility
4Cited by
2References
8Claims
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Key dates
| Filing date | Jul 21, 1994 |
| Grant date | Apr 1, 1997 |
| Priority date | — |
| Expiry date | Jul 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant DNA vectors which express chimeric T cell receptors are disclosed. These chimeric T cell receptors contain one human element, and the rest of the elements are all of the same, non-human animal species, such as a mouse. Of particular interest are chimeras where the human element is V.alpha. or V.beta.. The vectors are used to transfect cells which derive from the same non-human animal species as the non-human animal species of the chimera, and the resulting transfectants are used to produce monoclonal antibodies against the human element of the chimera.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.