Steroid sulphatase inhibitors
US5616574A · kind A · utility
28Cited by
0References
12Claims
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Assignee
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Key dates
| Filing date | Dec 27, 1994 |
| Grant date | Apr 1, 1997 |
| Priority date | — |
| Expiry date | Dec 27, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase are sulphamate esters of formula (I) ##STR1## where R.sub.1 and R.sub.2 are each H, alkyl, alkenyl, cycloalkyl or aryl, or together represent an alkylene group optionally containing a heteroatom e.g. --O-- or --NH--; and --O-- polycycle represents the residue of a polycyclic alcohol such as a sterol, preferably a 3-sterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.