(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzo pyrans

US5616610A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• John Evenden · Wellesley, US
• Eva Maria Hammarberg · Gately Drive, SE
• Hans S. Hansson · Stockholm, SE
• Sven Hellberg · Gately Drive, SE
• Lars George Johansson · Hagfors, SE
• Johan R. M. Lundkvist · Lund, SE
• Svante Ross · Gately Drive, SE
• Daniel Sohn · Gately Drive, SE
• Seth-Olov Thorberg · Haditha, IQ

Key dates

• Filing date: Jan 4, 1995
• Grant date: Apr 1, 1997
• Expiry date: Jan 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the general formula ##STR1## wherein R.sub.1 is n-propyl or cyclobutyl; R.sub.2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R.sub.3 is hydrogen; R.sub.4 is hydrogen or methyl; as (R)-enantiomer in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.