Osteoinduction substance, method of manufacturing the same, and bone filling material including the same
US5618339A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 22, 1996 |
| Grant date | Apr 8, 1997 |
| Priority date | — |
| Expiry date | Jul 22, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An osteoinduction substance is extracted from animal bones and essentially comprises Mg, Si, Ca, and Na. The osteoinduction substance is manufactured by subjecting the animal bone to acid dipping, liming, neutralization, thermal extraction, condensation, and dehydration to obtain gelatin. The gelatin is then subjected to deproteinization under a nonheat or a low-temperature condition to extract the osteoinduction substance. The osteoinduction substance is mixed with at least one of hydroxyapatite powder and chitosan to form a bone filling material. When the osteoinduction substance is mixed with chitosan sol, a bone filling material of a sheet type is obtained.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.