Biocompatible bioresorbable and non-toxic adhesive composition for surgical use
US5618551A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 20, 1995 |
| Grant date | Apr 8, 1997 |
| Priority date | — |
| Expiry date | Jan 20, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L24/104
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention relates to a biocompatible, bioresorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or in an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is preferably between approximately 5 and 30 by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as intermediate products in the preparation of the above-mentioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the above-mentioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive, composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesio…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.