Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5618563A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1993 |
| Grant date | Apr 8, 1997 |
| Priority date | — |
| Expiry date | Sep 10, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0024
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and method of manufacture used to form the PLAMs are selected on the basis of their degradation profiles: release of the topical anesthetic in a linear, controlled manner over a period of preferably two weeks and degradation in vivo with a half-life of less than six months, more preferably two weeks, to avoid localized inflammation. Alternatively, a non-inflammatory can be incorporated into the polymer with the local anesthetic to prevent inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.