Cells expressing calcium channel .alpha.2 subunit-encoding DNA, optionally with a reporter gene for screening assays

US5618720A · kind A · utility

Assignee

• Sibia Neurosciences Inc. · US

Inventors

• Steven B. Ellis · San Diego, US
• Mark E. Williams · Lively, US
• Michael M. Harpold · San Diego, US
• Arnold Schwartz · Bridgeport, US
• Jean Sartor · San Diego, US
• Robert Brenner · Austin, US

Key dates

• Filing date: Feb 15, 1995
• Grant date: Apr 8, 1997
• Expiry date: Feb 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

[DNAs] DNA molecules encoding mammalian calcium channel a.sub.1 and a.sub.2 subunits are provided. The [DNAs] DNA molecules are used to transform host cells which may also contain a reporter gene, the transcription of which is responsive to an ion or molecule capable of entering the cell through a calcium channel.