Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds

US5618814A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Uwe Bamberger · Ochsenhausen, DE
• Annerose Mauz · Riedlingen, DE

Key dates

• Filing date: Aug 2, 1994
• Grant date: Apr 8, 1997
• Expiry date: Aug 2, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula ##STR1## (wherein R.sub.a, R.sub.b and R.sub.c are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the physiologically acceptable salts thereof, which have, inter alia, valuable pharmacological properties, particularly in chemotherapy a sensitizing effect on resistant tumors, the use thereof and processes for preparing them.