Combinatorial sulfonamide library

US5618825A · kind A · utility

Assignee

• PHARMACOPEIA, LLC · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• Michael H. J. Ohlmeyer · Plainsboro, US
• Ian Henderson · Plainsboro, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Apr 8, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Combinatorial libraries are disclosed which are represented by Formula I: EQU (T'--L).sub.q -- S--C(O)--L'--II' I wherein: PA1 S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. Compounds which contain aryl sulfonamides, N-acyl derivatives, and N-substituted pyrrolidines and piperidines of the formula : EQU Y--A--CO--R.sup.1 are inhibitors of serine proteases and carbonic anhydrase isozymes. They are useful in the treatment of hyper-coagulation disease and ocular diseases such as glaucoma.