Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5618830A · kind A · utility
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24Claims
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Key dates
| Filing date | Sep 29, 1995 |
| Grant date | Apr 8, 1997 |
| Priority date | — |
| Expiry date | Sep 29, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/96
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.