Process for making HIV protease inhibitors

US5618939A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• David Askin · Hackettstown, US
• Paul J. Reider · Westfield, US
• Kai Rossen · Hanau, DE
• Richard J. Varsolona · Scotch Plains, US
• Ralph P. Volante · Rahway, US
• Kenneth M. Wells · Somerville, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Apr 8, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is disclosed for making a chiral compound of the formula ##STR1## comprising reacting an epoxide compound of the formula ##STR2## and an amide of the formula ##STR3## in the presence of a strong base at a low temperature.