Fatty acid derivatives and pharmaceutical compositions containing same

US5618955A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Raphael Mechoulam · Jerusalem, IL
• Aviva Beuer · Jerusalem, IL
• Lemir Hanus · Jerusalem, IL
• William Devane · Jerusalem, IL

Key dates

• Filing date: Jul 26, 1995
• Grant date: Apr 8, 1997
• Expiry date: Jul 26, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pure polyunsaturated fatty acid amides and their derivatives. These synthcally produced compounds are able to mimic naturally occuring anandamides in the brain and bind the cannabinoid receptor. The compounds exhibit physiological activity and are useful as active ingredients in pharmaceutical compositions for the treatment of inflammation, migraines, spasticity activity, glaucoma, multiple sclerosis. The active compounds can be provided in isotope-tagged form.