Prodrug esters of phosphonosulfonate squalene synthetase inhibitors and method
US5618964A · kind A · utility
23Cited by
1References
12Claims
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Apr 8, 1997 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4075
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New prodrug esters of salt forms of the phosphonosulfonate squalene synthetase inhibitor having the structure ##STR1## are provided wherein R is alkyl, arylalkyl, aryl or acylthioalkyl. These prodrug esters inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating atherosclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.