Glycolipid enzyme-polymer conjugates
US5620884A · kind A · utility
8Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 30, 1994 |
| Grant date | Apr 15, 1997 |
| Priority date | — |
| Expiry date | Nov 30, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.