Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals

US5620995A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus Weidmann · Kronberg, DE
• Karl-Heinz Baringhaus · Blieskastel, DE
• Georg Tschank · Frankfurt am Main, DE
• Martin Bickel · Frankfurt am Main, DE

Key dates

• Filing date: Dec 28, 1994
• Grant date: Apr 15, 1997
• Expiry date: Dec 28, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06139
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the formula I, to a process for their preparation and to their use as pharmaceuticals. ##STR1## In particular, the compounds are used as inhibitors of prolyl-4-hydroxylase and as inhibitors of collagen biosynthesis, as pharmaceuticals against fibrotic diseases of the liver, the lung and the skin.