Processes and intermediates for preparing macrocycles

US5621108A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Amos B. Smith, III · Yeadon, US
• Stephen M. Condon · Glenmoore, US
• Johnnie L. Leazer, Jr. · Piscataway, US
• Robert E. Maleczka · Lansing, US
• John A. McCauley · Maple Glen, US
• James William Leahy · San Leandro, US

Key dates

• Filing date: Dec 5, 1994
• Grant date: Apr 15, 1997
• Expiry date: Dec 5, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel processes for the preparation of lactam- and lactone-containing macrocyles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are also provided.