Process for the manufacture of form 1 ranitidine hydrochloride

US5621120A · kind A · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Jag Mohan Khanna · New Delhi, IN
• Naresh Kumar · Barwala, IN
• Brij Khera · Ahmedabad, IN
• Mahavir Singh Khanna · Delhi, IN

Key dates

• Filing date: Jun 24, 1994
• Grant date: Apr 15, 1997
• Expiry date: Jun 24, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the manufacture of Form 1 ranitidine hydrochloride (N-[2-[[[5-(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl-N'-methyl-2- nitro-1,1-ethenediamine) hydrochloride, is described. A process to convert ranitidine hydrochloride Form 2 to Form 1 is also described.