Polyether-substituted porphyrin anti-tumor agents

US5622685A · kind A · utility

Assignee

• DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS · DE

Inventors

• Hans-Jurgen F. Sinn · Fairfield, US
• Hans-Hermann Schrenk · Zeiskam, DE
• Wolfgang Maier-Borst · Dossenheim, DE
• Eckhard Friedrich · Kirchheimbolanden, DE
• Georgi Graschew · Wiesloch, DE
• Dieter Wohrle · Bremen, DE
• Thomas Klenner · Ingelheim am Rhein, DE

Key dates

• Filing date: Jun 7, 1995
• Grant date: Apr 22, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tumor-active or tumor-diagnostic substances having preferred accumulation in the tumor, which are characterized in that they have PA1 at least two phenolic hydroxyl and/or amino groups, PA1 at least one aliphatic amino group, or PA1 at least one phenolic hydroxyl and/or amino group and PA1 at least one aliphatic amino group and that these groups are substituted with polyethylene glycol chains whose polymerization degree n is 5 to 250 and whose terminal hydroxyl group is substituted by C.sub.1 -C.sub.12 alkyl ester or ether, each of the substances being substituted by at least two such polyethylene glycol chains.