Spheroid formulation
US5622722A · kind A · utility
80Cited by
4References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 5, 1994 |
| Grant date | Apr 22, 1997 |
| Priority date | — |
| Expiry date | Dec 5, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition comprising spheroids comprising a water-soluble active ingredient or a pharmaceutically acceptable salt thereof, microcrystalline cellulose and a sugar. Preferably the active ingredient is hydromorphone hydrochloride and the sugar is lactose. Surprisingly the incorporation of a sugar improves the dissolution rate of the spheroid formulation instead of reducing the dissolution rate by competing with the active ingredient for solubilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.