1-amino-3-phenoxy propane derivatives as modulator agents and their applications

US5622953A · kind A · utility

Assignee

• BASF SE

Inventors

• Bernd Janssen · Ludwigshafen, DE
• Andreas Kling · Mannheim, DE
• Stefan Mueller · Speyer, DE
• Kurt Ritter · Heidelberg, DE
• Rainer Schlecker · Bissersheim, DE
• Gerhard Keilhauer · Marlboro, US
• Cynthia Romerdahl · Wayland, US
• Ulrich Traugott · Mountain Lakes, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Apr 22, 1997
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: ##STR1## (in which A, B, R, R.sup.x, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.