Acylated aminoalkanimidazoles and - triazoles

US5622982A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Ingeborg Schuster · Wien, AT
• Helmut Egger · Wien, AT

Key dates

• Filing date: May 16, 1995
• Grant date: Apr 22, 1997
• Expiry date: May 16, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns azole compounds of formula ##STR1## wherein the substituents have various significances, in free form or salt form. They can be prepared e.g. by acylation, or by aziridine or oxazole ring opening. The compounds can be used as pharmaceuticals, especially as selective inhibitors of the 25-hydroxyvitamin D3--hydroxylases in the treatment of disorders of proliferation and differentiation in vitamin D--responsive tissues.