Amino-benzofuryl-and thienyl-derivatives

US5622989A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gabriele Br aunlich · Wuppertal, DE
• R udiger Fischer · Hanerau-Hademarschen, DE
• Mazen Es-Sayed · Langenfeld, DE
• Rudolf Hanko · Düsseldorf, DE
• Stephen Tudhope · Windsor, GB
• Graham Sturton · Maidenhead, GB
• Trevor S. Abram · Marlow, GB
• Wendy J. McDonald-Gibson · Wallingford, GB
• Mary F. Fitzgerald · Yarnton, GB

Key dates

• Filing date: May 23, 1995
• Grant date: Apr 22, 1997
• Expiry date: May 23, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the substituents. The compounds are useful for the treatment of actual and chronic inflammatory diseases, particularly of the airways and the gastro-intestinal tract.