Isolation and characterization of a novel chimpanzee lentivirus, designated simian immunodeficiency virus isolate cpz-ant
US5624795A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 11, 1993 |
| Grant date | Apr 29, 1997 |
| Priority date | — |
| Expiry date | Feb 11, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a retrovirus isolated from a chimpanzee and designated as SIV.sub.cpz-ant and to variants of this virus, having the following essential morphological and immunological properties: the virus exhibits a tropism for T4 lymphocytes, the virus does not exhibit cytopathic effect with the formation of giant cells in the lymphocytes that it infects, the virus has a diameter of approximately 130 nm, the virus possesses a magnesium dependent reverse transcriptase activity, it can be cultivated in T4 receptor-bearing immortalized cell-lines, lysates of the virus containing a p27 protein that is immunologically distinct from the p25 of HIV-1 and p19 protein of HTLV-1 on Western Blot, lysates of the virus containing a gp140 protein which is immunologically distinct from the gp120 of HIV-1 and gp140 of HTLV-1 by Western Blot analysis, the lysate of the virus contains an additional transmembrane glycoprotein with a molecular weight of 44,000 to 50,000 kD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.