Chemical compounds as inhibitors of amyloid beta protein production
US5624937A · kind A · utility
107Cited by
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12Claims
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Key dates
| Filing date | Mar 2, 1995 |
| Grant date | Apr 29, 1997 |
| Priority date | — |
| Expiry date | Mar 2, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D237/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula I in which ##STR1## Z is O or S; R.sup.11 is a halogen atom; PA1 R.sup.12 is a halogen atom or a trifluoromethyl group; and PA1 X is S, SO, SO.sub.2, O or NH; PA1 R.sup.4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of amyloid beta-protein production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.