Methods for synthesizing oligomers containing hydroxy acid units
US5625030A · kind A · utility
56Cited by
2References
20Claims
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Key dates
| Filing date | Nov 20, 1995 |
| Grant date | Apr 29, 1997 |
| Priority date | — |
| Expiry date | Nov 20, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K11/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for synthesizing oligomers containing hydroxy acids, and optionally containing other types of monomers or oligomers such as amino acids, carbohydrates, nucleotides and peptides, are provided which are rapid, simple, and readily automated. The oligomers have a C-terminal and an O, S or N-terminal end. The starting hydroxy acid can be covalently bound at either the C-terminal or O, S or N-terminal end to a solid support. The bond to the solid support can be an amide, thioester, ester, phosphate, silyl ether, carbamate, benzyl ether, or other linkage that can be cleaved either chemically or enzymatically.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.